Subject(s)
Anxiety Disorders , Severe Acute Respiratory Syndrome , Olfaction Disorders , COVID-19 , SeizuresABSTRACT
Background To understand the awareness of COVID-19 vaccine, the willingness to vaccinate and the influencing factors of willingness to vaccinate in inflammatory bowel disease (IBD) patients. Methods The online questionnaire was distributed to conduct a survey to analyze and evaluate the willingness, awareness and trust in vaccines of IBD patients. Bivariate analyses and logistic regression models were used to analysis influencing factors. Results We sent the questionnaire to the WeChat group for patient management and 304 patients responded, out of which 16 respondents had to be excluded and 288 respondents were included for the analysis. Among them, 209 patients vaccinated with COVID-19 vaccine. Among the non-vaccinated 79 patients, the main reasons for their concerns were afraid of vaccination aggravating IBD and fear of adverse effects. Our results showed that IBD patients with long disease duration were more willing to receive COVID-19 vaccination (P<0.05). We also observed that a high perception of benefits and cues to action to receive the vaccine were the two most important constructs affecting a definite intention for COVID-19 vaccination (P<0.05). Conclusions Patients with IBD have a more cautious attitude towards COVID-19 vaccination, which may lead to a higher rate of vaccine hesitancy. Further efforts should be made to protect patients with IBD from COVID-19 infections and achieve adequate vaccination coverage.
ABSTRACT
Background: To investigate the impact of the coronavirus disease (COVID-19) pandemic on the prevalence and outcome of pediatric severe sepsis in the Shandong Province of China from 2019 to 2020.Methods: Using the 2019-2020 data from the Interconnected Electronic Medical Record Data Sets of the Shandong Population Health Information Platform, a retrospective study was conducted to examine visits by patients aged up to 18 years who were diagnosed with severe sepsis or septic shock or bacterial/fungal infections combined with acute organ dysfunctions. The prevalence and mortality of these patients between 2019 and 2020 were compared. Results: There were no confirmed positive cases of COVID-19 among these patients. The number of cases and the yearly incidence rate of pediatric severe sepsis in hospitals decreased significantly (1098 vs 2143, 1.62/1000 vs 1.78/1000, P=0.01) along with the total number of hospitalized children (679608 vs 1204496) in the Shandong Province of China in 2020 compared to 2019. The hospital mortality of pediatric severe sepsis did not change significantly as it varied from 11.48% in 2019 to 12.84% in 2020 (P=0.283). The hospital costs, the proportion of pediatric severe sepsis admitted to ICU as well as those requiring mechanical ventilation increased in 2020 compared to 2019.Conclusion: After the outbreak of the COVID-19 pandemic, the number and the yearly incidence rate of pediatric severe sepsis among hospitalized children in the Shandong province decreased significantly, while the hospital mortality did not change significantly. The COVID-19 pandemic seemingly impacted favorably the epidemiology of pediatric severe sepsis.
Subject(s)
COVID-19ABSTRACT
Background: Multiorgan damage by SARS-CoV-2 results in alterations of many clinical measures associated with mortality of COVID-19. This research discussed the pioneering pathogenicity factors that lead to the extensive damage elusive. Objectives: A cohort of COVID-19 patients. Methods: : We conducted a correlational analysis of hospital outcomes with an independent cohort of COVID-19 patients and we also presented a death case to illustrate for time course of immune cell density. Results: : The results showed that dysregulated immune cell densities were correlated with hospitalization duration before death, not before discharge. High neutrophil densities allowed sorting out one third of total death cases while a density of less than 70% of the white blood cells allowed sorting out 70% of surviving cases. Conclusion: Collectively surged neutrophil was a top trigger for mortality in patients with COVID-19.
Subject(s)
COVID-19ABSTRACT
Background Worldwide spread of the novel coronavirus disease 2019 (COVID-19) has made hundreds of thousands people sick and fortunately many of them have been treated and discharged. However, it remains unclear how well the discharged patients were recovering. Chest CT scan, with demonstrated high sensitivity to COVID-19, was used here to examine clinical manifestations in patients at discharge.Methods This study registered retrospectively single-center case series of 180 discharged patients, all confirmed with COVID-19 at Wuhan Red Cross Hospital in Wuhan, China. Epidemiological, demographic, clinical, laboratory and treatment data were collected. CT imaging features of absorption vs progressive stage were compared and analyzed.Results Five pulmonary lobes were affected in 54 (30%) of the 180 patients at the absorption stage, comparing to 66% of them at the progressive stage (P=1.45×10-11). Forty five (25%) patients had pleural effusion on admission and 13 of them still carried hydrothorax when discharged as per standard discharge criteria(P=4.48×10-6). Besides, compared with those at progressive stage, 97 (54%) discharged patients had interlobular thickening (P=6.95×10-3) and 43% of them still presented adjacent pleura thickening (P=5.58×10-5). The median total CT score of discharged patients at absorption stage was lower than progressive stage (3 vs 12.5 ). The median total CT score recovery rate was 67% (range, 0-100%) and 139 (77%) patients showed less than 90% improvement at discharge.Conclusions A majority (77%) of the discharged patients had not recovered completely. The current discharge criteria may need to include 90% or higher CT score-based recovery rate.Authors Jingwen Li, Xi Long, Fang Fang, and Xuefei Lv contributed equally to this work.Authors Zhicheng Lin and Nian Xiong are joint last coauthors.